High systemic and tumor-associated IL8 correlates with reduced clinical benefit of PD-L1 blockade

Although elevated plasma interleukin-8 (pIL8) has been associated with poor outcome to immune checkpoint blockade (ICB),(1) this has not been comprehensively evaluated in large randomized studies. Here we analyzed circulating pIL8, and IL8 gene expression in peripheral blood mononuclear cells (PBMCs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Med
Prif Awduron: Yuen, Kobe C., Liu, Lifen, Gupta, Vinita, Madireddi, Shravan, Keerthivasan, Shilpa, Li, Congfen, Rishipathak, Deepali, Williams, Patrick, Kadel, Edward E., Koeppen, Hartmut, Chen, Ying-Jiun, Modrusan, Zora, Grogan, Jane L., Banchereau, Romain, Leng, Ning, Thastrom, AnnChristine, Shen, Xiadong, Hashimoto, Kenji, Tayama, Darren, van der Heijden, Michiel S., Rosenberg, Jonathan E., McDermott, David F., Powles, Thomas, Hegde, Priti S., Huseni, Mahrukh A., Mariathasan, Sanjeev
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286544/
https://ncbi.nlm.nih.gov/pubmed/32405063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0860-1
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