High systemic and tumor-associated IL8 correlates with reduced clinical benefit of PD-L1 blockade

Although elevated plasma interleukin-8 (pIL8) has been associated with poor outcome to immune checkpoint blockade (ICB),(1) this has not been comprehensively evaluated in large randomized studies. Here we analyzed circulating pIL8, and IL8 gene expression in peripheral blood mononuclear cells (PBMCs...

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Veröffentlicht in:Nat Med
Hauptverfasser: Yuen, Kobe C., Liu, Lifen, Gupta, Vinita, Madireddi, Shravan, Keerthivasan, Shilpa, Li, Congfen, Rishipathak, Deepali, Williams, Patrick, Kadel, Edward E., Koeppen, Hartmut, Chen, Ying-Jiun, Modrusan, Zora, Grogan, Jane L., Banchereau, Romain, Leng, Ning, Thastrom, AnnChristine, Shen, Xiadong, Hashimoto, Kenji, Tayama, Darren, van der Heijden, Michiel S., Rosenberg, Jonathan E., McDermott, David F., Powles, Thomas, Hegde, Priti S., Huseni, Mahrukh A., Mariathasan, Sanjeev
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286544/
https://ncbi.nlm.nih.gov/pubmed/32405063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0860-1
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