High systemic and tumor-associated IL8 correlates with reduced clinical benefit of PD-L1 blockade

Although elevated plasma interleukin-8 (pIL8) has been associated with poor outcome to immune checkpoint blockade (ICB),(1) this has not been comprehensively evaluated in large randomized studies. Here we analyzed circulating pIL8, and IL8 gene expression in peripheral blood mononuclear cells (PBMCs...

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Publicat a:Nat Med
Autors principals: Yuen, Kobe C., Liu, Lifen, Gupta, Vinita, Madireddi, Shravan, Keerthivasan, Shilpa, Li, Congfen, Rishipathak, Deepali, Williams, Patrick, Kadel, Edward E., Koeppen, Hartmut, Chen, Ying-Jiun, Modrusan, Zora, Grogan, Jane L., Banchereau, Romain, Leng, Ning, Thastrom, AnnChristine, Shen, Xiadong, Hashimoto, Kenji, Tayama, Darren, van der Heijden, Michiel S., Rosenberg, Jonathan E., McDermott, David F., Powles, Thomas, Hegde, Priti S., Huseni, Mahrukh A., Mariathasan, Sanjeev
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286544/
https://ncbi.nlm.nih.gov/pubmed/32405063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0860-1
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