In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales

Immunogenetic variation in humans is important in research, clinical diagnosis and increasingly a target for therapeutic intervention. Two highly polymorphic loci play critical roles, namely the human leukocyte antigen (HLA) system, which is the human version of the major histocompatibility complex...

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Vydáno v:Brief Bioinform
Hlavní autoři: Chen, Jieming, Madireddi, Shravan, Nagarkar, Deepti, Migdal, Maciej, Vander Heiden, Jason, Chang, Diana, Mukhyala, Kiran, Selvaraj, Suresh, Kadel, Edward E, Brauer, Matthew J, Mariathasan, Sanjeev, Hunkapiller, Julie, Jhunjhunwala, Suchit, Albert, Matthew L, Hammer, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Case Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138874/
https://ncbi.nlm.nih.gov/pubmed/32940337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bib/bbaa223
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