Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

BACKGROUND: CD8+ tissue-resident memory T (T(RM)) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy. METHODS: Here, we test this by combining high-dimensional s...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Immunother Cancer
المؤلفون الرئيسيون: Banchereau, Romain, Chitre, Avantika S., Scherl, Alexis, Wu, Thomas D., Patil, Namrata S., de Almeida, Patricia, Kadel, III, Edward E., Madireddi, Shravan, Au-Yeung, Amelia, Takahashi, Chikara, Chen, Ying-Jiun, Modrusan, Zora, McBride, Jacqueline, Nersesian, Rhea, El-Gabry, Ehab A., Robida, Mark D., Hung, Jeffrey C., Kowanetz, Marcin, Zou, Wei, McCleland, Mark, Caplazi, Patrick, Eshgi, Shadi Toghi, Koeppen, Hartmut, Hegde, Priti S., Mellman, Ira, Mathews, W. Rodney, Powles, Thomas, Mariathasan, Sanjeev, Grogan, Jane, O'Gorman, William E
التنسيق: Artigo
اللغة:Inglês
منشور في: BMJ Publishing Group 2021
الموضوعات:
Immunotherapy Biomarkers
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032254/
https://ncbi.nlm.nih.gov/pubmed/33827905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002231
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