Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

BACKGROUND: CD8+ tissue-resident memory T (T(RM)) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy. METHODS: Here, we test this by combining high-dimensional s...

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Gepubliceerd in:J Immunother Cancer
Hoofdauteurs: Banchereau, Romain, Chitre, Avantika S., Scherl, Alexis, Wu, Thomas D., Patil, Namrata S., de Almeida, Patricia, Kadel, III, Edward E., Madireddi, Shravan, Au-Yeung, Amelia, Takahashi, Chikara, Chen, Ying-Jiun, Modrusan, Zora, McBride, Jacqueline, Nersesian, Rhea, El-Gabry, Ehab A., Robida, Mark D., Hung, Jeffrey C., Kowanetz, Marcin, Zou, Wei, McCleland, Mark, Caplazi, Patrick, Eshgi, Shadi Toghi, Koeppen, Hartmut, Hegde, Priti S., Mellman, Ira, Mathews, W. Rodney, Powles, Thomas, Mariathasan, Sanjeev, Grogan, Jane, O'Gorman, William E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Publishing Group 2021
Onderwerpen:
Immunotherapy Biomarkers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032254/
https://ncbi.nlm.nih.gov/pubmed/33827905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002231
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