Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

BACKGROUND: CD8+ tissue-resident memory T (T(RM)) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy. METHODS: Here, we test this by combining high-dimensional s...

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Bibliografski detalji
Izdano u:J Immunother Cancer
Glavni autori: Banchereau, Romain, Chitre, Avantika S., Scherl, Alexis, Wu, Thomas D., Patil, Namrata S., de Almeida, Patricia, Kadel, III, Edward E., Madireddi, Shravan, Au-Yeung, Amelia, Takahashi, Chikara, Chen, Ying-Jiun, Modrusan, Zora, McBride, Jacqueline, Nersesian, Rhea, El-Gabry, Ehab A., Robida, Mark D., Hung, Jeffrey C., Kowanetz, Marcin, Zou, Wei, McCleland, Mark, Caplazi, Patrick, Eshgi, Shadi Toghi, Koeppen, Hartmut, Hegde, Priti S., Mellman, Ira, Mathews, W. Rodney, Powles, Thomas, Mariathasan, Sanjeev, Grogan, Jane, O'Gorman, William E
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2021
Teme:
Immunotherapy Biomarkers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032254/
https://ncbi.nlm.nih.gov/pubmed/33827905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002231
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