Genome-Wide Mapping of Human DNA Replication by Optical Replication Mapping Supports a Stochastic Model of Eukaryotic Replication

The heterogeneous nature of eukaryotic replication kinetics and the low efficiency of individual initiation sites make mapping the location and timing of replication initiation in human cells difficult. To address this challenge, we have developed Optical Replication Mapping (ORM), a high-throughput...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Wang, Weitao, Klein, Kyle, Proesmans, Karel, Yang, Hongbo, Marchal, Claire, Zhu, Xiaopeng, Borrman, Tyler, Hastie, Alex, Weng, Zhiping, Bechhoefer, John, Chen, Chun-Long, Gilbert, David M., Rhind, Nicholas
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286344/
https://ncbi.nlm.nih.gov/pubmed/34157308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.05.024
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