Genome-Wide Mapping of Human DNA Replication by Optical Replication Mapping Supports a Stochastic Model of Eukaryotic Replication

The heterogeneous nature of eukaryotic replication kinetics and the low efficiency of individual initiation sites make mapping the location and timing of replication initiation in human cells difficult. To address this challenge, we have developed Optical Replication Mapping (ORM), a high-throughput...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Wang, Weitao, Klein, Kyle, Proesmans, Karel, Yang, Hongbo, Marchal, Claire, Zhu, Xiaopeng, Borrman, Tyler, Hastie, Alex, Weng, Zhiping, Bechhoefer, John, Chen, Chun-Long, Gilbert, David M., Rhind, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286344/
https://ncbi.nlm.nih.gov/pubmed/34157308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.05.024
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