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Kidney-specific Klotho Gene Deletion Causes Aortic Aneurysm via Hyperphosphatemia

Klotho is an aging-suppressor gene. The purpose of this study was to determine whether deletion of the klotho gene in kidneys causes aortic aneurysm (AA) and investigate the underlying mechanisms. Klotho-floxed alleles and tamoxifen-inducible kidney specific CreER(T2) mice were crossed to generate K...

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Detaylı Bibliyografya
Yayımlandı:Hypertension
Asıl Yazarlar: Wang, Qiongxin, Wang, Shirley, Sun, Zhongjie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285030/
https://ncbi.nlm.nih.gov/pubmed/34176284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.121.17299
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