In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage

OBJECTIVE: Klotho is an aging-suppressor gene which leads to accelerated aging when disrupted. This study was designed to investigate whether glutathione reductase (GR), a critical intracellular antioxidant enzyme, is involved in the pathogenesis of kidney damages associated with accelerated aging i...

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Vydáno v:Redox Biol
Hlavní autoři: Gao, Diansa, Wang, Shirley, Lin, Yi, Sun, Zhongjie
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476318/
https://ncbi.nlm.nih.gov/pubmed/32863229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101692
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