Structure-Activity Relationships of Pyrimidine Nucleotides Containing a 5′-α,β-Methylene Diphosphonate at the P2Y(6) Receptor

The G(q)-coupled P2Y(6) receptor (P2Y(6)R) is a component of the purinergic signaling system and functions in inflammatory, cardiovascular and metabolic processes. UDP, the native P2Y(6)R agonist and P2Y(14)R partial agonist, is subject to hydrolysis by ectonucleotidases. Therefore, we have synthesi...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Oliva, Paola, Scortichini, Mirko, Dobelmann, Clemens, Jain, Shanu, Gopinatth, Varun, Toti, Kiran S., Phung, Ngan B., Junker, Anna, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276771/
https://ncbi.nlm.nih.gov/pubmed/34048882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.128137
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