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Structure-Activity Relationships of Pyrimidine Nucleotides Containing a 5′-α,β-Methylene Diphosphonate at the P2Y(6) Receptor
The G(q)-coupled P2Y(6) receptor (P2Y(6)R) is a component of the purinergic signaling system and functions in inflammatory, cardiovascular and metabolic processes. UDP, the native P2Y(6)R agonist and P2Y(14)R partial agonist, is subject to hydrolysis by ectonucleotidases. Therefore, we have synthesi...
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| Udgivet i: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8276771/ https://ncbi.nlm.nih.gov/pubmed/34048882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.128137 |
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