Pyrimidine nucleotides containing a (S)-methanocarba ring as P2Y(6) receptor agonists

Both agonists and antagonists of the UDP-activated P2Y(6) receptor (P2Y(6)R) have been proposed for therapeutic use, in conditions such as cancer, inflammation, neurodegeneration and diabetes. Uracil nucleotides containing a south-bicyclo[3.1.0]hexane ((S)-methanocarba) ring system in place of the r...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Toti, Kiran S., Jain, Shanu, Ciancetta, Antonella, Balasubramanian, Ramachandran, Chakraborty, Saibal, Surujdin, Ryan, Shi, Zhen-Dan, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798474/
https://ncbi.nlm.nih.gov/pubmed/29423136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00397h
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