Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors

CD73 converts AMP to immunosuppressive adenosine, and its inhibition was proposed as a new strategy for cancer treatment. We synthesized 5′-O-[(phosphonomethyl)phosphonic acid] derivatives of purine and pyrimidine nucleosides, which represent nucleoside diphosphate analogs, and compared their CD73 i...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Junker, Anna, Renn, Christian, Dobelmann, Clemens, Namasivayam, Vigneshwaran, Jain, Shanu, Losenkova, Karolina, Irjala, Heikki, Duca, Sierra, Balasubramanian, Ramachandran, Chakraborty, Saibal, Börgel, Frederik, Zimmermann, Herbert, Yegutkin, Gennady G., Müller, Christa E., Jacobson, Kenneth A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526958/
https://ncbi.nlm.nih.gov/pubmed/30895781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00164
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller