Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).

The adenosine producing enzyme ecto-5'-nucleotidase (5'-NT) is not normally expressed during thymocyte development until the medullary stage. To determine whether earlier expression would lead to adenosine accumulation and/or be deleterious for thymocyte maturation, thymic purine metabolis...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Resta, R, Hooker, S W, Laurent, A B, Jamshedur Rahman, S M, Franklin, M, Knudsen, T B, Nadon, N L, Thompson, L F
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507850/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9045870/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119211
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