Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).

The adenosine producing enzyme ecto-5'-nucleotidase (5'-NT) is not normally expressed during thymocyte development until the medullary stage. To determine whether earlier expression would lead to adenosine accumulation and/or be deleterious for thymocyte maturation, thymic purine metabolis...

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Main Authors: Resta, R, Hooker, S W, Laurent, A B, Jamshedur Rahman, S M, Franklin, M, Knudsen, T B, Nadon, N L, Thompson, L F
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC507850/
https://ncbi.nlm.nih.gov/pubmed/9045870
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