Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors

CD73 converts AMP to immunosuppressive adenosine, and its inhibition was proposed as a new strategy for cancer treatment. We synthesized 5′-O-[(phosphonomethyl)phosphonic acid] derivatives of purine and pyrimidine nucleosides, which represent nucleoside diphosphate analogs, and compared their CD73 i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Junker, Anna, Renn, Christian, Dobelmann, Clemens, Namasivayam, Vigneshwaran, Jain, Shanu, Losenkova, Karolina, Irjala, Heikki, Duca, Sierra, Balasubramanian, Ramachandran, Chakraborty, Saibal, Börgel, Frederik, Zimmermann, Herbert, Yegutkin, Gennady G., Müller, Christa E., Jacobson, Kenneth A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526958/
https://ncbi.nlm.nih.gov/pubmed/30895781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00164
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