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T-cell receptor β-selection is required at the CD4(+)CD8(+) stage of human T-cell development

T-cell development is predicated on the successful rearrangement of the T-cell receptor (TCR) gene loci, which encode for antigen-specific receptors. Recombination Activating Gene (RAG) 2 is required for TCR gene rearrangements, which occur during specific stages of T-cell development. Here, we diff...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Chen, Edward L. Y., Brauer, Patrick M., Martinez, Elisa C., Huang, Xiaotian, Yu, Ning, Anderson, Michele K., Li, Yang, Zúñiga-Pflücker, Juan Carlos
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274368/
https://ncbi.nlm.nih.gov/pubmed/33941655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2100141
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