Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

Chronic infection provokes alterations in inflammatory and suppressive pathways that potentially affect the function and integrity of multiple tissues, impacting both ongoing immune control and restorative immune therapies. Here we demonstrate that chronic lymphocytic choriomeningitis virus infectio...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Elsaesser, Heidi J., Mohtashami, Mahmood, Osokine, Ivan, Snell, Laura M., Cunningham, Cameron R., Boukhaled, Giselle M., McGavern, Dorian B., Zúñiga-Pflücker, Juan Carlos, Brooks, David G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071912/
https://ncbi.nlm.nih.gov/pubmed/32094187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913776117
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