Cellular and Molecular Requirements for the Selection of in vitro-Generated CD8 T Cells Reveals a Role for Notch()

Differentiation of CD8 single-positive (SP) T-cells is predicated by the ability of lymphocyte progenitors to integrate multiple signaling cues provided by the thymic microenvironment. In the thymus and the OP9-DL1 system for T-cell development, Notch signals are required for progenitors to commit t...

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Autori principali: Dervovic, Dzana D., Liang, Haydn C-Y., Cannons, Jennifer L., Elford, Alisha R., Mohtashami, Mahmood, Ohashi, Pamela S., Schwartzberg, Pamela L., Zúñiga-Pflücker, Juan Carlos
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801448/
https://ncbi.nlm.nih.gov/pubmed/23851691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300417
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