Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8(+) T Cell Survival, Differentiation, and Function

Activated phosphoinositide 3-kinase delta syndrome (APDS), also known as p110 delta-activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency (PASLI), is an autosomal dominant primary human immunodeficiency (PID) caused by heterozygous gain-of-function mutations in PIK3CD,...

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Vydáno v:Front Immunol
Hlavní autoři: Cannons, Jennifer L., Preite, Silvia, Kapnick, Senta M., Uzel, Gulbu, Schwartzberg, Pamela L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082933/
https://ncbi.nlm.nih.gov/pubmed/30116245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01758
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