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Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay
Loss of the fragile X protein FMRP is a leading cause of intellectual disability and autism(1,2), but the underlying mechanism remains poorly understood. We report that FMRP deficiency results in hyperactivated nonsense-mediated mRNA decay (NMD)(3,4) in human SH-SY5Y neuroblastoma cells and fragile...
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| Publicado no: | Nat Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8273690/ https://ncbi.nlm.nih.gov/pubmed/33420492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00618-1 |
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