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A novel Bromine-containing paroxetine analog provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter

The serotonin transporter (SERT) is the primary target for the selective serotonin reuptake inhibitors (SSRIs). However, the structural basis for the extraordinarily high binding affinity of the widely-prescribed SSRI, paroxetine, to human SERT (hSERT) has not yet been fully elucidated. Our previous...

詳細記述

保存先:
書誌詳細
出版年:ACS Chem Neurosci
主要な著者: Slack, Rachel D., Abramyan, Ara M., Tang, Helen, Meena, Sitaram, Davis, Bruce A., Bonifazi, Alessandro, Giancola, JoLynn B., Deschamps, Jeffrey R., Naing, Sett, Yano, Hideaki, Singh, Satinder K., Newman, Amy Hauck, Shi, Lei
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272913/
https://ncbi.nlm.nih.gov/pubmed/31424193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00375
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