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The Glu102 mutation disrupts higher-order oligomerization of the sigma 1 receptor
The sigma 1 receptor (σ1R) is a unique endoplasmic reticulum membrane protein. Its ligands have been shown to possess therapeutic potential for neurological and substance use disorders among others. The E102Q mutation of σ1R has been found to elicit familial cases of amyotrophic lateral sclerosis (A...
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| Publicado no: | Comput Struct Biotechnol J |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Research Network of Computational and Structural Biotechnology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7005341/ https://ncbi.nlm.nih.gov/pubmed/32055286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.12.012 |
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