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The Glu102 mutation disrupts higher-order oligomerization of the sigma 1 receptor
The sigma 1 receptor (σ1R) is a unique endoplasmic reticulum membrane protein. Its ligands have been shown to possess therapeutic potential for neurological and substance use disorders among others. The E102Q mutation of σ1R has been found to elicit familial cases of amyotrophic lateral sclerosis (A...
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| Izdano u: | Comput Struct Biotechnol J |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Research Network of Computational and Structural Biotechnology
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7005341/ https://ncbi.nlm.nih.gov/pubmed/32055286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.12.012 |
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