A novel Bromine-containing paroxetine analog provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter

The serotonin transporter (SERT) is the primary target for the selective serotonin reuptake inhibitors (SSRIs). However, the structural basis for the extraordinarily high binding affinity of the widely-prescribed SSRI, paroxetine, to human SERT (hSERT) has not yet been fully elucidated. Our previous...

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Bibliografiset tiedot
Julkaisussa:ACS Chem Neurosci
Päätekijät: Slack, Rachel D., Abramyan, Ara M., Tang, Helen, Meena, Sitaram, Davis, Bruce A., Bonifazi, Alessandro, Giancola, JoLynn B., Deschamps, Jeffrey R., Naing, Sett, Yano, Hideaki, Singh, Satinder K., Newman, Amy Hauck, Shi, Lei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272913/
https://ncbi.nlm.nih.gov/pubmed/31424193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00375
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