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Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics
The serotonin transporter (SERT) is one of the primary targets for medications to treat neuropsychiatric disorders and functions by exploiting pre-existing ion gradients of Na(+), Cl(−), and K(+) to translocate serotonin from the synaptic cleft into the presynaptic neuron. Although recent hSERT crys...
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| Veröffentlicht in: | Neuropharmacology |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6494725/ https://ncbi.nlm.nih.gov/pubmed/30391505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2018.10.040 |
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