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A novel Bromine-containing paroxetine analog provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter
The serotonin transporter (SERT) is the primary target for the selective serotonin reuptake inhibitors (SSRIs). However, the structural basis for the extraordinarily high binding affinity of the widely-prescribed SSRI, paroxetine, to human SERT (hSERT) has not yet been fully elucidated. Our previous...
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| Publicat a: | ACS Chem Neurosci |
|---|---|
| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8272913/ https://ncbi.nlm.nih.gov/pubmed/31424193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00375 |
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