A novel Bromine-containing paroxetine analog provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter

The serotonin transporter (SERT) is the primary target for the selective serotonin reuptake inhibitors (SSRIs). However, the structural basis for the extraordinarily high binding affinity of the widely-prescribed SSRI, paroxetine, to human SERT (hSERT) has not yet been fully elucidated. Our previous...

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Foilsithe in:ACS Chem Neurosci
Main Authors: Slack, Rachel D., Abramyan, Ara M., Tang, Helen, Meena, Sitaram, Davis, Bruce A., Bonifazi, Alessandro, Giancola, JoLynn B., Deschamps, Jeffrey R., Naing, Sett, Yano, Hideaki, Singh, Satinder K., Newman, Amy Hauck, Shi, Lei
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272913/
https://ncbi.nlm.nih.gov/pubmed/31424193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00375
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