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Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization
BIM is the master BH3-only BCL-2 family regulator of lymphocyte survival. To understand how long-term loss of BIM affects apoptotic resistance in T cells we studied animals with T cell-specific deletion of Bim. Unlike CD19(CRE) Bim(fl/fl) animals, LCK(CRE) Bim(fl/fl) mice have pronounced early lymph...
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| Publicado no: | Apoptosis |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8265391/ https://ncbi.nlm.nih.gov/pubmed/31993851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-020-01593-6 |
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