Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide

BCL-2 family proteins are central regulators of apoptosis and represent prime therapeutic targets for overcoming cell death resistance in malignancies. However, plasticity of anti-apoptotic members, such as MCL-1, often allows for a switch in cell death dependency patterns that lie outside the bindi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hadji, Abbas, Schmitt, Greta K., Schnorenberg, Mathew R., Roach, Lauren, Hickey, Connie M., Leak, Logan B., Tirrell, Matthew V., LaBelle, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817437/
https://ncbi.nlm.nih.gov/pubmed/31692812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27262
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