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Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
BCL-2 family proteins constitute a critical control point for the regulation of apoptosis. Protein interaction between BCL-2 members is a prominent mechanism of control and is mediated through the amphipathic α-helical BH3 segment, an essential death domain. We used a chemical strategy, termed hydro...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1360987/ https://ncbi.nlm.nih.gov/pubmed/15353804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1099191 |
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