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Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

BCL-2 family proteins constitute a critical control point for the regulation of apoptosis. Protein interaction between BCL-2 members is a prominent mechanism of control and is mediated through the amphipathic α-helical BH3 segment, an essential death domain. We used a chemical strategy, termed hydro...

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Detalhes bibliográficos
Main Authors: Walensky, Loren D., Kung, Andrew L., Escher, Iris, Malia, Thomas J., Barbuto, Scott, Wright, Renee D., Wagner, Gerhard, Verdine, Gregory L., Korsmeyer, Stanley J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360987/
https://ncbi.nlm.nih.gov/pubmed/15353804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1099191
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