Challenges in Targeting a Basic Helix–Loop–Helix Transcription Factor with Hydrocarbon-Stapled Peptides

Basic helix–loop–helix (bHLH) transcription factors play critical roles in organism development and disease by regulating cell proliferation and differentiation. Transcriptional activity, whether by bHLH homo- or heterodimerization, is dependent on protein–protein and protein–DNA interactions mediat...

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Publicado en:ACS Chem Biol
Main Authors: Edwards, Amanda L., Meijer, Dimphna H., Guerra, Rachel M., Molenaar, Remco J., Alberta, John A., Bernal, Federico, Bird, Gregory H., Stiles, Charles D., Walensky, Loren D.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534327/
https://ncbi.nlm.nih.gov/pubmed/27643505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00465
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