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Cellular Uptake and Ultrastructural Localization Underlie the Proapoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide

Hydrocarbon stapling has been applied to restore and stabilize the α-helical structure of bioactive peptides for biochemical, structural, cellular, and in vivo studies. The peptide sequence, in addition to the composition and location of the installed staple, can dramatically influence the propertie...

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書目詳細資料
發表在:ACS Chem Biol
Main Authors: Edwards, Amanda L., Wachter, Franziska, Lammert, Margaret, Huhn, Annissa J., Luccarelli, James, Bird, Gregory H., Walensky, Loren D.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839450/
https://ncbi.nlm.nih.gov/pubmed/26151238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00214
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