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The endogenous tryptophan-derived photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) is a nanomolar photosensitizer that can be harnessed for the photodynamic elimination of skin cancer cells in vitro and in vivo

UV-chromophores contained in human skin may act as endogenous sensitizers of photooxidative stress and can be employed therapeutically for the photodynamic elimination of malignant cells. Here we report that 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan-derived photoproduct and endogenous aryl...

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Detalhes bibliográficos
Publicado no:Photochem Photobiol
Main Authors: Justiniano, Rebecca, de Faria Lopes, Lohanna, Perer, Jessica, Hua, Anh, Park, Sophia L., Jandova, Jana, Baptista, Maurício S., Wondrak, Georg T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265325/
https://ncbi.nlm.nih.gov/pubmed/32767762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/php.13321
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