The tryptophan-derived endogenous arylhydrocarbon receptor ligand 6-formylindolo[3,2-b]carbazole (FICZ) is a nanomolar UVA-photosensitizer in epidermal keratinocytes

Endogenous UVA-chromophores may act as sensitizers of oxidative stress underlying cutaneous photoaging and photocarcinogenesis, but the molecular identity of non-DNA key chromophores displaying UVA-driven photodyamic activity in human skin remains largely undefined. Here we report that 6-formylindol...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Park, Sophia L., Justiniano, Rebecca, Williams, Joshua D., Cabello, Christopher M., Qiao, Shuxi, Wondrak, Georg T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430374/
https://ncbi.nlm.nih.gov/pubmed/25431849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.503
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