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Oxidative stress induced by UVA photoactivation of the tryptophan UVB photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) inhibits nucleotide excision repair in human cells

Potentially mutagenic DNA lesions induced by UVB (wavelengths 280–320 nm) are important risk factors for solar ultraviolet (UV) radiation-induced skin cancer. The carcinogenicity of the more abundant UVA (320–400 nm) is less well understood but is generally regarded to reflect its interaction with c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Brem, Reto, Macpherson, Peter, Guven, Melisa, Karran, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487344/
https://ncbi.nlm.nih.gov/pubmed/28655934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04614-8
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