Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy

Chemotherapy has been reported to upregulate sphingomylinases and increase cellular ceramide, often linked to the induction to cell death. In this work, we show that sublethal doses of doxorubicin and vorinostat still increased cellular ceramide, which was located predominantly at the plasma membran...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Canals, Daniel, Salamone, Silvia, Santacreu, Bruno Jaime, Nemeth, Erika, Aguilar, Daniel, Hernandez-Corbacho, María José, Adada, Mohamad, Staquicini, Daniela I., Arap, Wadih, Pasqualini, Renata, Haley, John, Obeid, Lina M, Hannun, Yusuf A
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265206/
https://ncbi.nlm.nih.gov/pubmed/32307766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202000205R
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