A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Chinese hamster ovary (CHO) cells are the most widely used host for the expression of therapeutic proteins. Recently, significant progress has been made due to advances in genome sequence and annotation quality to unravel the black box CHO. Nevertheless, in many cases the link between genotype and p...

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Detalles Bibliográficos
Publicado en:Biotechnol Rep (Amst)
Main Authors: Schmieder, Valerie, Novak, Neža, Dhiman, Heena, Nguyen, Ly Ngoc, Serafimova, Evgenija, Klanert, Gerald, Baumann, Martina, Kildegaard, Helene Faustrup, Borth, Nicole
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261548/
https://ncbi.nlm.nih.gov/pubmed/34277363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.btre.2021.e00649
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