A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

Media and feed optimization have fueled many-fold improvements in mammalian biopharmaceutical production, but genome editing offers an emerging avenue for further enhancing cell metabolism and bioproduction. However, the complexity of metabolism, involving thousands of genes, makes it unclear which...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Metab Eng
Main Authors: Cour Karottki, Karen Julie, Hefzi, Hooman, Li, Songyuan, Pedersen, Lasse Ebdrup, Spahn, Philipp N., Joshi, Chintan, Ruckerbauer, David, Hernandez Bort, Juan A., Thomas, Alex, Lee, Jae Seong, Borth, Nicole, Lee, Gyun Min, Kildegaard, Helene Faustrup, Lewis, Nathan E.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193919/
https://ncbi.nlm.nih.gov/pubmed/33813034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2021.03.017
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki