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Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway
Chinese hamster ovary (CHO) cells are the most widely used mammalian hosts for production of therapeutic proteins. However, development of recombinant CHO cell lines has been hampered by unstable and variable transgene expression caused by random integration. Here we demonstrate efficient targeted g...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4339809/ https://ncbi.nlm.nih.gov/pubmed/25712033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08572 |
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