Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

Chinese hamster ovary (CHO) cells are widely used in the biopharmaceutical industry as a host for the production of complex pharmaceutical proteins. Thus genome engineering of CHO cells for improved product quality and yield is of great interest. Here, we demonstrate for the first time the efficacy...

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Veröffentlicht in:Biotechnol Bioeng
Hauptverfasser: Ronda, Carlotta, Pedersen, Lasse Ebdrup, Hansen, Henning Gram, Kallehauge, Thomas Beuchert, Betenbaugh, Michael J, Nielsen, Alex Toftgaard, Kildegaard, Helene Faustrup
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312910/
https://ncbi.nlm.nih.gov/pubmed/24827782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.25233
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