Awakening dormant glycosyltransferases in CHO cells with CRISPRa

Chinese hamster ovary (CHO) cells are the preferred workhorse for the biopharmaceutical industry, and CRISPR/Cas9 has proven powerful for generating targeted gene perturbations in CHO cells. Here we expand the CRISPR engineering toolbox with CRISPR activation (CRISPRa) to increase transcription of e...

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Detalhes bibliográficos
Publicado no:Biotechnol Bioeng
Main Authors: Karottki, Karen Julie la Cour, Hefzi, Hooman, Xiong, Kai, Shamie, Isaac, Hansen, Anders Holmgaard, Li, Songyuan, Pedersen, Lasse Ebdrup, Li, Shangzhong, Lee, Jae Seong, Lee, Gyun Min, Kildegaard, Helene Faustrup, Lewis, Nathan E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261405/
https://ncbi.nlm.nih.gov/pubmed/31631317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27199
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