Reduced Apoptosis in Chinese Hamster Ovary Cells via Optimized CRISPR Interference

Chinese hamster ovary (CHO) cells are widely used for biopharmaceutical protein production. One challenge limiting CHO cell productivity is apoptosis stemming from cellular stress during protein production. Here we applied CRISPR interference (CRISPRi) to downregulate the endogenous expression of ap...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biotechnol Bioeng
Main Authors: Xiong, Kai, Marquart, Kim Fabiano, la Cour Karottki, Karen Julie, Li, Shangzhong, Shamie, Isaac, Lee, Jae Seong, Gerling, Signe, Yeo, Nan Cher, Chavez, Alejandro, Lee, Gyun Min, Lewis, Nathan E., Kildegaard, Helene Faustrup
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545153/
https://ncbi.nlm.nih.gov/pubmed/30883679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26969
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados