Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations

Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we investigated potential causes for an unstable phenotype by comparing cell lines that express sta...

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Opis bibliograficzny
Wydane w:Comput Struct Biotechnol J
Główni autorzy: Dhiman, Heena, Campbell, Marguerite, Melcher, Michael, Smith, Kevin D., Borth, Nicole
Format: Artigo
Język:Inglês
Wydane: Research Network of Computational and Structural Biotechnology 2020
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710658/
https://ncbi.nlm.nih.gov/pubmed/33304461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.11.008
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