Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations

Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we investigated potential causes for an unstable phenotype by comparing cell lines that express sta...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Comput Struct Biotechnol J
Prif Awduron: Dhiman, Heena, Campbell, Marguerite, Melcher, Michael, Smith, Kevin D., Borth, Nicole
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Research Network of Computational and Structural Biotechnology 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710658/
https://ncbi.nlm.nih.gov/pubmed/33304461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.11.008
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