Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese hamster ovary cells

MicroRNAs (miRNAs) are small non-coding RNAs (∼22 nucleotides) which regulate gene expression by silencing mRNA translation. MiRNAs are transcribed as long primary transcripts, which are enzymatically processed by Drosha/Dgcr8, in the nucleus, and by Dicer in the cytoplasm, into mature miRNAs. The i...

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Bibliographic Details
Published in:Biotechnol J
Main Authors: Klanert, Gerald, Jadhav, Vaibhav, Chanoumidou, Konstantina, Grillari, Johannes, Borth, Nicole, Hackl, Matthias
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2014
Subjects:
Technical Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282078/
https://ncbi.nlm.nih.gov/pubmed/24323929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201300216
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