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Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation

CHO cells are the mammalian cell line of choice for recombinant production of therapeutic proteins. However, their low rate of proliferation limits obtainable space-time yields due to inefficient biomass accumulation. We set out to correlate microRNA transcription to cell-specific growth-rate by mic...

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Библиографические подробности
Опубликовано в: :J Biotechnol
Главные авторы: Hackl, Matthias, Jadhav, Vaibhav, Klanert, Gerald, Karbiener, Michael, Scheideler, Marcel, Grillari, Johannes, Borth, Nicole
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier Science Publishers 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247382/
https://ncbi.nlm.nih.gov/pubmed/24486028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiotec.2013.12.018
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