Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations

Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we investigated potential causes for an unstable phenotype by comparing cell lines that express sta...

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Pubblicato in:Comput Struct Biotechnol J
Autori principali: Dhiman, Heena, Campbell, Marguerite, Melcher, Michael, Smith, Kevin D., Borth, Nicole
Natura: Artigo
Lingua:Inglês
Pubblicazione: Research Network of Computational and Structural Biotechnology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710658/
https://ncbi.nlm.nih.gov/pubmed/33304461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.11.008
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